Drug interactions
Avapritinib + Isoniazid
Severity: Moderate
Avapritinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid may inhibit CYP3A4 and increase avapritinib exposure. This could heighten the risk of intracranial hemorrhage, cognitive effects and other dose-related toxicity.
What this interaction means in plain words
Avapritinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibits CYP3A4, reducing avapritinib metabolism.
What to do
Monitor for cognitive changes, bleeding and edema, and consider reducing the avapritinib dose per labeling for CYP3A inhibitors. Prefer an alternative if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Isoniazid?
MediHelp rates the interaction as moderate. Avapritinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid may inhibit CYP3A4 and increase avapritinib exposure. This could heighten the risk of intracranial hemorrhage, cognitive effects and other dose-related toxicity.
How serious is the interaction between Avapritinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive changes, bleeding and edema, and consider reducing the avapritinib dose per labeling for CYP3A inhibitors. Prefer an alternative if feasible.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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