Drug interactions
Avapritinib + Metronidazole
Severity: Minor
Avapritinib and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole is at most a weak CYP3A4 inhibitor, and no meaningful rise in avapritinib exposure is established. The legacy classification as a moderate inhibitor is not supported.
What this interaction means in plain words
Avapritinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Avapritinib belongs to Oncology; Metronidazole belongs to Anti Parasitic.
Why it happens
Weak, poorly established CYP3A4 inhibition by metronidazole.
What to do
No dose adjustment is normally needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Metronidazole?
MediHelp rates the interaction as minor. Avapritinib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole is at most a weak CYP3A4 inhibitor, and no meaningful rise in avapritinib exposure is established. The legacy classification as a moderate inhibitor is not supported.
How serious is the interaction between Avapritinib and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is normally needed; monitor for avapritinib adverse effects such as cognitive effects and bleeding.
What other medicines interact with Metronidazole?
MediHelp also lists interactions of Metronidazole with, for example, Ethanol, Pimozide, Amiodarone. The full list is on the Metronidazole page.
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