Drug interactions
Avapritinib + Olanzapine
Severity: Moderate
Avapritinib and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib causes CNS effects including cognitive impairment, somnolence and dizziness, which may add to the sedation of olanzapine. Olanzapine is not a meaningful CYP3A4 inhibitor, so the main concern is additive CNS depression.
What this interaction means in plain words
Avapritinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects.
What to do
Monitor for excessive sedation, confusion and falls, particularly at initiation. Reduce the olanzapine dose if sedation becomes problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Olanzapine?
MediHelp rates the interaction as moderate. Avapritinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib causes CNS effects including cognitive impairment, somnolence and dizziness, which may add to the sedation of olanzapine. Olanzapine is not a meaningful CYP3A4 inhibitor, so the main concern is additive CNS depression.
How serious is the interaction between Avapritinib and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, confusion and falls, particularly at initiation. Reduce the olanzapine dose if sedation becomes problematic.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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