Drug interactions
Avapritinib + Pimozide
Severity: Moderate
Avapritinib and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and drowsiness, and pimozide may add to sedation. Pimozide also prolongs the QT interval, and avapritinib has been associated with QT effects, so the combination warrants attention.
What this interaction means in plain words
Avapritinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS effects and possible additive QT prolongation; no clinically relevant CYP3A4 inhibition by pimozide is established.
What to do
Monitor ECG and electrolytes, and watch for sedation and cognitive changes. Consider an alternative if QT prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Pimozide?
MediHelp rates the interaction as moderate. Avapritinib and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and drowsiness, and pimozide may add to sedation. Pimozide also prolongs the QT interval, and avapritinib has been associated with QT effects, so the combination warrants attention.
How serious is the interaction between Avapritinib and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for sedation and cognitive changes. Consider an alternative if QT prolongation develops.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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