Drug interactions
Avapritinib + Remifentanil
Severity: Moderate
Avapritinib and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and drowsiness, and remifentanil is a potent opioid with sedative and respiratory depressant effects. Together they may increase CNS impairment.
What this interaction means in plain words
Avapritinib and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; the avapritinib effect is not fully characterized.
What to do
Monitor sedation, cognition and respiratory status when remifentanil is given to patients on avapritinib, and titrate remifentanil conservatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Remifentanil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Remifentanil?
MediHelp rates the interaction as moderate. Avapritinib and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and drowsiness, and remifentanil is a potent opioid with sedative and respiratory depressant effects. Together they may increase CNS impairment.
How serious is the interaction between Avapritinib and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, cognition and respiratory status when remifentanil is given to patients on avapritinib, and titrate remifentanil conservatively.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
