Drug interactions
Avapritinib + Topiramate
Severity: Moderate
Avapritinib and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and cognitive adverse effects. Combined use may worsen memory problems, confusion and drowsiness.
What this interaction means in plain words
Avapritinib and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS and cognitive effects (pharmacodynamic).
What to do
Monitor cognition and alertness, and reduce the dose of one agent if impairment develops. Counsel on driving safety.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Topiramate?
MediHelp rates the interaction as moderate. Avapritinib and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and cognitive adverse effects. Combined use may worsen memory problems, confusion and drowsiness.
How serious is the interaction between Avapritinib and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and alertness, and reduce the dose of one agent if impairment develops. Counsel on driving safety.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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