Drug interactions
Avapritinib + Triprolidine
Severity: Moderate
Avapritinib and Triprolidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avapritinib can cause cognitive effects and somnolence, and triprolidine adds sedative H1-antihistamine effects. The combination may worsen drowsiness, confusion or memory problems.
What this interaction means in plain words
Avapritinib and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Triprolidine belongs to Respiratory.
Why it happens
Additive CNS depressant effects; no pharmacokinetic mechanism is established.
What to do
Monitor for sedation and cognitive changes and consider a non-sedating antihistamine. Advise caution with driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triprolidine
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Triprolidine?
MediHelp rates the interaction as moderate. Avapritinib and Triprolidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avapritinib can cause cognitive effects and somnolence, and triprolidine adds sedative H1-antihistamine effects. The combination may worsen drowsiness, confusion or memory problems.
How serious is the interaction between Avapritinib and Triprolidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes and consider a non-sedating antihistamine. Advise caution with driving and machinery.
What other medicines interact with Triprolidine?
MediHelp also lists interactions of Triprolidine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Triprolidine page.
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