Drug interactions
Deferiprone + Obinutuzumab
Severity: Major
Deferiprone and Obinutuzumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab frequently causes neutropenia, sometimes prolonged or late-onset. With deferiprone, the risk of severe neutropenia and infection may be compounded.
What this interaction means in plain words
Deferiprone and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Obinutuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity affecting neutrophils.
What to do
Avoid if possible; if both are needed, monitor absolute neutrophil count more frequently and interrupt deferiprone for neutropenia or infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Deferiprone with Obinutuzumab?
MediHelp rates the interaction as major. Deferiprone and Obinutuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Obinutuzumab frequently causes neutropenia, sometimes prolonged or late-onset. With deferiprone, the risk of severe neutropenia and infection may be compounded.
How serious is the interaction between Deferiprone and Obinutuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are needed, monitor absolute neutrophil count more frequently and interrupt deferiprone for neutropenia or infection.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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