Drug interactions
Axicabtagene ciloleucel + Pemetrexed
Severity: Moderate
Axicabtagene ciloleucel and Pemetrexed: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy and immunosuppressive agents may impair CAR T-cell expansion and function, and the combination adds infection risk. No specific pharmacokinetic interaction is established.
What this interaction means in plain words
Axicabtagene ciloleucel and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axicabtagene ciloleucel belongs to Oncology; Pemetrexed belongs to Oncology.
Why it happens
Cytotoxic and myelosuppressive effects of pemetrexed may reduce CAR T-cell activity, with additive immunosuppression; mechanism not firmly established.
What to do
Avoid pemetrexed around leukapheresis and CAR T infusion per treating protocol, and monitor for infection and cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pemetrexed
Other interactions of Axicabtagene ciloleucel
Frequently asked questions
Can I take Axicabtagene ciloleucel with Pemetrexed?
MediHelp rates the interaction as moderate. Axicabtagene ciloleucel and Pemetrexed can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy and immunosuppressive agents may impair CAR T-cell expansion and function, and the combination adds infection risk. No specific pharmacokinetic interaction is established.
How serious is the interaction between Axicabtagene ciloleucel and Pemetrexed?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pemetrexed around leukapheresis and CAR T infusion per treating protocol, and monitor for infection and cytopenias.
What other medicines interact with Pemetrexed?
MediHelp also lists interactions of Pemetrexed with, for example, Bacitracin, Brexucabtagene autoleucel, Celecoxib. The full list is on the Pemetrexed page.
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