Drug interactions
Axitinib + Azelastine-fluticasone
Severity: Minor
Axitinib and Azelastine-fluticasone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is cleared mainly by CYP3A4, and the fluticasone component of this product is a CYP3A4 substrate rather than a meaningful inhibitor. Azelastine is not an established CYP3A4 inhibitor, so a clinically relevant rise in axitinib exposure from the nasal spray is not expected.
What this interaction means in plain words
Axitinib and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Azelastine-fluticasone belongs to Respiratory.
Why it happens
Weak theoretical CYP3A4 effect only; not established with intranasal use.
What to do
No adjustment is needed. Monitor axitinib tolerability as usual, including blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Azelastine-fluticasone?
MediHelp rates the interaction as minor. Axitinib and Azelastine-fluticasone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is cleared mainly by CYP3A4, and the fluticasone component of this product is a CYP3A4 substrate rather than a meaningful inhibitor. Azelastine is not an established CYP3A4 inhibitor, so a clinically relevant rise in axitinib exposure from the nasal spray is not expected.
How serious is the interaction between Axitinib and Azelastine-fluticasone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor axitinib tolerability as usual, including blood pressure.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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