Drug interactions
Axitinib + Chloramphenicol
Severity: Moderate
Axitinib and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit CYP3A4 and raise axitinib exposure. This may increase hypertension, diarrhea, fatigue and other axitinib toxicities.
What this interaction means in plain words
Axitinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated axitinib metabolism.
What to do
Prefer an alternative antibiotic. If co-administered, monitor blood pressure and tolerability and consider reducing the axitinib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Chloramphenicol?
MediHelp rates the interaction as moderate. Axitinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can inhibit CYP3A4 and raise axitinib exposure. This may increase hypertension, diarrhea, fatigue and other axitinib toxicities.
How serious is the interaction between Axitinib and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If co-administered, monitor blood pressure and tolerability and consider reducing the axitinib dose.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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