Drug interactions
Axitinib + Felodipine
Severity: Minor
Axitinib and Felodipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, but felodipine is at most a weak CYP3A4 inhibitor, so a meaningful rise in axitinib levels is unlikely. Both can affect blood pressure, and axitinib commonly causes hypertension.
What this interaction means in plain words
Axitinib and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Felodipine belongs to Cardiovascular.
Why it happens
Weak, probably clinically insignificant CYP3A4 inhibition by felodipine.
What to do
No dose adjustment is expected. Monitor blood pressure during axitinib therapy and adjust antihypertensives as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Felodipine?
MediHelp rates the interaction as minor. Axitinib and Felodipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is metabolized mainly by CYP3A4, but felodipine is at most a weak CYP3A4 inhibitor, so a meaningful rise in axitinib levels is unlikely. Both can affect blood pressure, and axitinib commonly causes hypertension.
How serious is the interaction between Axitinib and Felodipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is expected. Monitor blood pressure during axitinib therapy and adjust antihypertensives as usual.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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