Drug interactions
Axitinib + Hydrochlorothiazide-losartan
Severity: Minor
Axitinib and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, and losartan is not a clinically meaningful CYP3A4 inhibitor. No clinically relevant increase in axitinib exposure is expected. Axitinib can independently raise blood pressure, which may need attention in patients on antihypertensives.
What this interaction means in plain words
Axitinib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
No established pharmacokinetic mechanism; losartan is only a weak CYP3A4 substrate and not a relevant inhibitor.
What to do
No dose adjustment is required. Monitor blood pressure during axitinib therapy as it may itself cause hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Axitinib and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is metabolized mainly by CYP3A4, and losartan is not a clinically meaningful CYP3A4 inhibitor. No clinically relevant increase in axitinib exposure is expected. Axitinib can independently raise blood pressure, which may need attention in patients on antihypertensives.
How serious is the interaction between Axitinib and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor blood pressure during axitinib therapy as it may itself cause hypertension.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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