Drug interactions
Axitinib + Imatinib
Severity: Moderate
Axitinib and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP3A4 and may raise axitinib concentrations, increasing the risk of hypertension, diarrhea, hepatotoxicity and bleeding. Imatinib is a moderate rather than strong inhibitor, so the effect is likely modest.
What this interaction means in plain words
Axitinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated axitinib metabolism by imatinib.
What to do
Monitor blood pressure and for axitinib adverse effects; reduce the axitinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Imatinib?
MediHelp rates the interaction as moderate. Axitinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP3A4 and may raise axitinib concentrations, increasing the risk of hypertension, diarrhea, hepatotoxicity and bleeding. Imatinib is a moderate rather than strong inhibitor, so the effect is likely modest.
How serious is the interaction between Axitinib and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for axitinib adverse effects; reduce the axitinib dose if toxicity occurs.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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