Drug interactions
Axitinib + Methoxsalen
Severity: Minor
Axitinib and Methoxsalen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen inhibits CYP2A6 and has some CYP3A4 inhibitory activity, so it may raise axitinib levels. Higher exposure could increase hypertension, diarrhea and hepatic effects.
What this interaction means in plain words
Axitinib and Methoxsalen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Methoxsalen belongs to Anti Fungals.
Why it happens
Possible CYP3A4 inhibition by methoxsalen, reducing axitinib metabolism.
What to do
Monitor blood pressure and adverse effects, and reduce the axitinib dose if toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Axitinib with Methoxsalen?
MediHelp rates the interaction as minor. Axitinib and Methoxsalen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Methoxsalen inhibits CYP2A6 and has some CYP3A4 inhibitory activity, so it may raise axitinib levels. Higher exposure could increase hypertension, diarrhea and hepatic effects.
How serious is the interaction between Axitinib and Methoxsalen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adverse effects, and reduce the axitinib dose if toxicity develops.
What other medicines interact with Axitinib?
MediHelp also lists interactions of Axitinib with, for example, Amobarbital, Apalutamide, Atazanavir. The full list is on the Axitinib page.
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