Drug interactions
Axitinib + Nicardipine
Severity: Moderate
Axitinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine is a moderate CYP3A4 inhibitor and may modestly increase axitinib exposure. Higher axitinib levels can increase hypertension, diarrhea, and other dose-related toxicities.
What this interaction means in plain words
Axitinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated axitinib metabolism reduces its clearance.
What to do
Monitor blood pressure and adverse effects closely and reduce the axitinib dose if toxicity occurs. Nicardipine may also help treat axitinib-related hypertension, so adjust doses according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Axitinib and Nicardipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nicardipine
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Nicardipine?
MediHelp rates the interaction as moderate. Axitinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine is a moderate CYP3A4 inhibitor and may modestly increase axitinib exposure. Higher axitinib levels can increase hypertension, diarrhea, and other dose-related toxicities.
How serious is the interaction between Axitinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and adverse effects closely and reduce the axitinib dose if toxicity occurs. Nicardipine may also help treat axitinib-related hypertension, so adjust doses according to response.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
