Drug interactions
Axitinib + Quinidine
Severity: Moderate
Axitinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, and quinidine inhibits this enzyme only weakly to moderately, so the effect is likely modest. Higher axitinib exposure could increase hypertension, diarrhea and other dose-related adverse effects.
What this interaction means in plain words
Axitinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Axitinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP3A4 and P-glycoprotein, which may reduce axitinib clearance.
What to do
Monitor blood pressure and tolerability of axitinib, and reduce the dose if adverse effects emerge. A strong CYP3A4 inhibitor dose reduction is not routinely needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Quinidine?
MediHelp rates the interaction as moderate. Axitinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Axitinib is metabolized mainly by CYP3A4, and quinidine inhibits this enzyme only weakly to moderately, so the effect is likely modest. Higher axitinib exposure could increase hypertension, diarrhea and other dose-related adverse effects.
How serious is the interaction between Axitinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and tolerability of axitinib, and reduce the dose if adverse effects emerge. A strong CYP3A4 inhibitor dose reduction is not routinely needed.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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