Drug interactions
Axitinib + Vinblastine
Severity: Minor
Axitinib and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Axitinib is metabolized mainly by CYP3A4, and vinblastine is not a recognized clinically important inhibitor of this enzyme. Although vinblastine is a CYP3A4 substrate, a meaningful rise in axitinib exposure is not established.
What this interaction means in plain words
Axitinib and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Theoretical competition for CYP3A4 metabolism; vinblastine is not a known significant inhibitor.
What to do
No dose adjustment is needed; monitor for axitinib adverse effects such as hypertension and diarrhea as routine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Vinblastine?
MediHelp rates the interaction as minor. Axitinib and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Axitinib is metabolized mainly by CYP3A4, and vinblastine is not a recognized clinically important inhibitor of this enzyme. Although vinblastine is a CYP3A4 substrate, a meaningful rise in axitinib exposure is not established.
How serious is the interaction between Axitinib and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for axitinib adverse effects such as hypertension and diarrhea as routine.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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