Drug interactions
Axitinib + Ziprasidone
Severity: Minor
Axitinib and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is metabolized partly by CYP3A4 but is not a clinically important CYP3A4 inhibitor, so a meaningful rise in axitinib levels is unlikely. Both drugs may affect cardiac repolarization to a limited degree.
What this interaction means in plain words
Axitinib and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Axitinib belongs to Oncology; Ziprasidone belongs to Central Nervous System.
Why it happens
No established pharmacokinetic mechanism; ziprasidone is not a significant CYP3A4 inhibitor.
What to do
No dose adjustment is needed. Consider an ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Axitinib
- Amobarbital + Axitinib Major
- Apalutamide + Axitinib Major
- Atazanavir + Axitinib Major
- Axitinib + Carbamazepine Major
- Axitinib + Clarithromycin Major
- Axitinib + Cobicistat Major
Frequently asked questions
Can I take Axitinib with Ziprasidone?
MediHelp rates the interaction as minor. Axitinib and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziprasidone is metabolized partly by CYP3A4 but is not a clinically important CYP3A4 inhibitor, so a meaningful rise in axitinib levels is unlikely. Both drugs may affect cardiac repolarization to a limited degree.
How serious is the interaction between Axitinib and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Consider an ECG if other QT-prolonging risk factors are present.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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