Drug interactions
Azapropazone + Dalteparin
Severity: Major
Azapropazone and Dalteparin: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azapropazone is an NSAID that inhibits platelet function and can injure the gastric mucosa, so combining it with dalteparin raises bleeding risk. The legacy claim of protein-binding displacement is not relevant to heparins.
What this interaction means in plain words
Azapropazone and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects of NSAID-related platelet inhibition and gastrointestinal mucosal damage with the anticoagulant action of dalteparin.
What to do
Avoid the combination where possible and choose paracetamol or another analgesic. If unavoidable, monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Fragmin 10000 IU/0.4ml solution for injection - SmPC sections 4.3/4.5 (class statement: NSAIDs; "An enhancement of the anticoagulant effect by other anticoagulant/antiplatelet agents e.g. aspirin/dipyridamole, GP IIb/IIIa receptor antagonists, Vitamin K ant") — electronic medicines compendium (UK SmPC)
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Azapropazone with Dalteparin?
MediHelp rates the interaction as major. Azapropazone and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Azapropazone is an NSAID that inhibits platelet function and can injure the gastric mucosa, so combining it with dalteparin raises bleeding risk. The legacy claim of protein-binding displacement is not relevant to heparins.
How serious is the interaction between Azapropazone and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose paracetamol or another analgesic. If unavoidable, monitor for bleeding and hemoglobin.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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