Drug interactions
Azathioprine + Etrasimod
Severity: Moderate
Azathioprine and Etrasimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod lowers circulating lymphocytes, and combining it with azathioprine may further increase immunosuppression and infection risk. The combination has not been studied.
What this interaction means in plain words
Azathioprine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Etrasimod belongs to Gastrointestinal Tract.
Why it happens
Additive immunosuppression from sphingosine-1-phosphate receptor modulation, which sequesters lymphocytes, and purine antimetabolite activity.
What to do
Avoid combining where possible. If used, monitor complete blood counts including lymphocytes and watch for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Azathioprine with Etrasimod?
MediHelp rates the interaction as moderate. Azathioprine and Etrasimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etrasimod lowers circulating lymphocytes, and combining it with azathioprine may further increase immunosuppression and infection risk. The combination has not been studied.
How serious is the interaction between Azathioprine and Etrasimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If used, monitor complete blood counts including lymphocytes and watch for infection.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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