Drug interactions
Azathioprine + Trastuzumab
Severity: Moderate
Azathioprine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab increases neutropenia when given with myelosuppressive agents, and azathioprine is myelosuppressive and immunosuppressive. The combination may raise the risk of neutropenia and infection.
What this interaction means in plain words
Azathioprine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azathioprine belongs to Gastrointestinal Tract; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression and immunosuppression.
What to do
Monitor complete blood counts and signs of infection, and reduce azathioprine dose if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicated
- Azathioprine + Bcg vaccine live Contraindicated
- Azathioprine + Febuxostat Contraindicated
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Azathioprine with Trastuzumab?
MediHelp rates the interaction as moderate. Azathioprine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab increases neutropenia when given with myelosuppressive agents, and azathioprine is myelosuppressive and immunosuppressive. The combination may raise the risk of neutropenia and infection.
How serious is the interaction between Azathioprine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection, and reduce azathioprine dose if neutropenia develops.
What other medicines interact with Azathioprine?
MediHelp also lists interactions of Azathioprine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Febuxostat. The full list is on the Azathioprine page.
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