Drug interactions
Azelastine + Brompheniramine
Severity: Moderate
Azelastine and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a first-generation sedating antihistamine, and combining it with azelastine duplicates antihistaminic therapy. This may increase drowsiness, dry mouth and impaired performance.
What this interaction means in plain words
Azelastine and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Brompheniramine belongs to Respiratory.
Why it happens
Additive H1-receptor antagonism with CNS depressant and anticholinergic effects.
What to do
Avoid using two antihistamines concurrently where possible. If both are needed, warn about drowsiness and monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Brompheniramine
Frequently asked questions
Can I take Azelastine with Brompheniramine?
MediHelp rates the interaction as moderate. Azelastine and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a first-generation sedating antihistamine, and combining it with azelastine duplicates antihistaminic therapy. This may increase drowsiness, dry mouth and impaired performance.
How serious is the interaction between Azelastine and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antihistamines concurrently where possible. If both are needed, warn about drowsiness and monitor for anticholinergic effects.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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