Drug interactions
Azelastine + Chlorzoxazone
Severity: Moderate
Azelastine and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant that can cause drowsiness and dizziness. Azelastine may add to these effects and reduce alertness.
What this interaction means in plain words
Azelastine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from H1-antagonism and central muscle relaxant activity.
What to do
Counsel about additive drowsiness and avoid driving until response is known. Avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Azelastine with Chlorzoxazone?
MediHelp rates the interaction as moderate. Azelastine and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant that can cause drowsiness and dizziness. Azelastine may add to these effects and reduce alertness.
How serious is the interaction between Azelastine and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about additive drowsiness and avoid driving until response is known. Avoid alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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