Drug interactions
Azelastine + Cyclizine
Severity: Moderate
Azelastine and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating antihistamines, so taking them together can cause more drowsiness and reduced concentration. Anticholinergic effects of cyclizine may also add to the burden.
What this interaction means in plain words
Azelastine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Cyclizine belongs to Respiratory.
Why it happens
Additive H1-antihistamine mediated CNS depression.
What to do
Avoid concurrent use where possible, or counsel the patient about sedation and avoid driving. Monitor older patients for confusion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Azelastine with Cyclizine?
MediHelp rates the interaction as moderate. Azelastine and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating antihistamines, so taking them together can cause more drowsiness and reduced concentration. Anticholinergic effects of cyclizine may also add to the burden.
How serious is the interaction between Azelastine and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, or counsel the patient about sedation and avoid driving. Monitor older patients for confusion.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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