Drug interactions
Azelastine + Doxepin
Severity: Moderate
Azelastine and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong antihistamine and anticholinergic activity. With azelastine, drowsiness, impaired psychomotor function and anticholinergic effects may be increased.
What this interaction means in plain words
Azelastine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression and H1 antagonism.
What to do
Monitor for oversedation and anticholinergic effects, especially in older adults. Counsel on driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Azelastine with Doxepin?
MediHelp rates the interaction as moderate. Azelastine and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong antihistamine and anticholinergic activity. With azelastine, drowsiness, impaired psychomotor function and anticholinergic effects may be increased.
How serious is the interaction between Azelastine and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, especially in older adults. Counsel on driving and alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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