Drug interactions
Azelastine + Isavuconazonium
Severity: Minor
Azelastine and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine is a weak CYP3A4 inhibitor in vitro at most, and isavuconazole is a CYP3A4 substrate, so a small increase in isavuconazole exposure is theoretically possible. The effect is expected to be small, especially with nasal azelastine.
What this interaction means in plain words
Azelastine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine belongs to Respiratory; Isavuconazonium belongs to Anti Fungals.
Why it happens
Possible weak inhibition of CYP3A4-mediated isavuconazole metabolism.
What to do
No dose change is generally needed. Monitor for isavuconazole adverse effects such as liver enzyme elevation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azelastine and Isavuconazonium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azelastine
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Azelastine with Isavuconazonium?
MediHelp rates the interaction as minor. Azelastine and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine is a weak CYP3A4 inhibitor in vitro at most, and isavuconazole is a CYP3A4 substrate, so a small increase in isavuconazole exposure is theoretically possible. The effect is expected to be small, especially with nasal azelastine.
How serious is the interaction between Azelastine and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for isavuconazole adverse effects such as liver enzyme elevation.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
