Drug interactions
Azelastine + Loxapine
Severity: Moderate
Azelastine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are sedating, so combined use can intensify drowsiness and slow psychomotor function. Loxapine also has anticholinergic and hypotensive effects that can add to the burden.
What this interaction means in plain words
Azelastine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1-receptor blockade and antipsychotic antihistaminic and dopaminergic antagonism.
What to do
Monitor sedation and orthostatic symptoms, and reduce the dose of one agent if oversedation occurs. Counsel patients on driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Azelastine with Loxapine?
MediHelp rates the interaction as moderate. Azelastine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are sedating, so combined use can intensify drowsiness and slow psychomotor function. Loxapine also has anticholinergic and hypotensive effects that can add to the burden.
How serious is the interaction between Azelastine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic symptoms, and reduce the dose of one agent if oversedation occurs. Counsel patients on driving and machinery.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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