Drug interactions
Azelastine + Maprotiline
Severity: Moderate
Azelastine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant with antihistaminic and anticholinergic properties. Together with azelastine, drowsiness, dizziness and impaired psychomotor performance may be increased.
What this interaction means in plain words
Azelastine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from combined H1-receptor antagonism.
What to do
Monitor for oversedation and anticholinergic effects, especially in older adults. Counsel on avoiding driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Azelastine with Maprotiline?
MediHelp rates the interaction as moderate. Azelastine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant with antihistaminic and anticholinergic properties. Together with azelastine, drowsiness, dizziness and impaired psychomotor performance may be increased.
How serious is the interaction between Azelastine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic effects, especially in older adults. Counsel on avoiding driving until tolerance is established.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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