Drug interactions
Azelastine + Oxymorphone
Severity: Moderate
Azelastine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may increase oxymorphone-related sedation and respiratory depression. Oxymorphone is a potent opioid, so added CNS depressants can produce clinically significant effects.
What this interaction means in plain words
Azelastine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from H1-antagonist sedation and mu-opioid agonism.
What to do
Monitor sedation and respiratory status, using the lowest effective opioid dose. Avoid alcohol and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Azelastine with Oxymorphone?
MediHelp rates the interaction as moderate. Azelastine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azelastine may increase oxymorphone-related sedation and respiratory depression. Oxymorphone is a potent opioid, so added CNS depressants can produce clinically significant effects.
How serious is the interaction between Azelastine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, using the lowest effective opioid dose. Avoid alcohol and other CNS depressants.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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