Drug interactions
Azelastine + Quetiapine
Severity: Moderate
Azelastine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is markedly sedating and combined use with azelastine may further increase drowsiness, dizziness and impaired coordination. Falls and next-day impairment are the main concerns.
What this interaction means in plain words
Azelastine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism of both drugs and other sedating receptor effects of quetiapine.
What to do
Monitor for excessive sedation and orthostatic symptoms, particularly at initiation. Advise avoiding alcohol and hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Azelastine with Quetiapine?
MediHelp rates the interaction as moderate. Azelastine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is markedly sedating and combined use with azelastine may further increase drowsiness, dizziness and impaired coordination. Falls and next-day impairment are the main concerns.
How serious is the interaction between Azelastine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostatic symptoms, particularly at initiation. Advise avoiding alcohol and hazardous activities.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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