Drug interactions
Azelastine + Secobarbital
Severity: Moderate
Azelastine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent sedative-hypnotics, and adding a sedating antihistamine can produce excessive sedation, impaired coordination and, at higher doses, respiratory depression. The risk is greater with oral azelastine, alcohol or other depressants.
What this interaction means in plain words
Azelastine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A potentiation by secobarbital and H1 antagonism by azelastine.
What to do
Use the lowest effective doses and monitor level of consciousness and respiratory function. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Azelastine with Secobarbital?
MediHelp rates the interaction as moderate. Azelastine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are potent sedative-hypnotics, and adding a sedating antihistamine can produce excessive sedation, impaired coordination and, at higher doses, respiratory depression. The risk is greater with oral azelastine, alcohol or other depressants.
How serious is the interaction between Azelastine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor level of consciousness and respiratory function. Counsel patients to avoid alcohol and driving.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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