Drug interactions
Azelastine + Sufentanil
Severity: Moderate
Azelastine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid and azelastine can add to sedation. Excess sedation and respiratory depression may occur, mostly in unmonitored settings.
What this interaction means in plain words
Azelastine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Monitor sedation and respiration and reduce the opioid dose as needed. Avoid other sedatives and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Azelastine with Sufentanil?
MediHelp rates the interaction as moderate. Azelastine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a very potent opioid and azelastine can add to sedation. Excess sedation and respiratory depression may occur, mostly in unmonitored settings.
How serious is the interaction between Azelastine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiration and reduce the opioid dose as needed. Avoid other sedatives and alcohol.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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