Drug interactions
Azelastine + Thioridazine
Severity: Moderate
Azelastine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so use together may increase drowsiness and impair psychomotor performance. Thioridazine also strongly prolongs the QT interval, so the full regimen should be reviewed for additional risks.
What this interaction means in plain words
Azelastine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine belongs to Respiratory; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism and phenothiazine antihistaminic, anticholinergic and antidopaminergic effects.
What to do
Monitor for oversedation and advise against driving until response is known. Maintain ECG and electrolyte monitoring as required for thioridazine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Azelastine with Thioridazine?
MediHelp rates the interaction as moderate. Azelastine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so use together may increase drowsiness and impair psychomotor performance. Thioridazine also strongly prolongs the QT interval, so the full regimen should be reviewed for additional risks.
How serious is the interaction between Azelastine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise against driving until response is known. Maintain ECG and electrolyte monitoring as required for thioridazine.
What other medicines interact with Azelastine?
MediHelp also lists interactions of Azelastine with, for example, Calcium / magnesium / potassium / sodium oxybates, Methadone, Sodium oxybate. The full list is on the Azelastine page.
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