Drug interactions
Azelastine-fluticasone + Brimonidine
Severity: Minor
Azelastine-fluticasone and Brimonidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brimonidine can cause drowsiness and fatigue, mainly with systemic absorption from eye drops, and azelastine can also sedate. Concurrent use may modestly add to CNS depression.
What this interaction means in plain words
Azelastine-fluticasone and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Brimonidine belongs to Miscellaneous.
Why it happens
Additive CNS depression via alpha2-agonism and antihistamine sedation.
What to do
Advise caution with driving and other alertness-requiring tasks, and monitor for excess drowsiness, especially in the elderly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Brimonidine
- Brimonidine + Isocarboxazid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Brimonidine + Phenelzine Contraindicated
- Brimonidine + Procarbazine Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Brimonidine + Selegiline Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Brimonidine?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Brimonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Brimonidine can cause drowsiness and fatigue, mainly with systemic absorption from eye drops, and azelastine can also sedate. Concurrent use may modestly add to CNS depression.
How serious is the interaction between Azelastine-fluticasone and Brimonidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise caution with driving and other alertness-requiring tasks, and monitor for excess drowsiness, especially in the elderly.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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