Drug interactions
Azelastine-fluticasone + Chloral hydrate
Severity: Moderate
Azelastine-fluticasone and Chloral hydrate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloral hydrate is a sedative-hypnotic, and azelastine may add to drowsiness. The combination can increase sedation and impair alertness, particularly in children and older adults.
What this interaction means in plain words
Azelastine-fluticasone and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Chloral hydrate belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Monitor for oversedation, especially in children and the elderly. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Chloral hydrate
- Calcium / magnesium / potassium / sodium oxybates + Chloral hydrate Contraindicated
- Chloral hydrate + Sodium oxybate Contraindicated
- Alfentanil + Chloral hydrate Major
- Alprazolam + Chloral hydrate Major
- Amobarbital + Chloral hydrate Major
- Belladonna and opium + Chloral hydrate Major
Frequently asked questions
Can I take Azelastine-fluticasone with Chloral hydrate?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Chloral hydrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloral hydrate is a sedative-hypnotic, and azelastine may add to drowsiness. The combination can increase sedation and impair alertness, particularly in children and older adults.
How serious is the interaction between Azelastine-fluticasone and Chloral hydrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, especially in children and the elderly. Avoid alcohol and other sedatives.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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