Drug interactions
Azelastine-fluticasone + Clozapine
Severity: Moderate
Azelastine-fluticasone and Clozapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clozapine is strongly sedating and anticholinergic, and azelastine may add drowsiness. The combination can increase sedation and impair psychomotor function.
What this interaction means in plain words
Azelastine-fluticasone and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Clozapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression via antihistaminic effects.
What to do
Monitor for oversedation and advise on driving. Reduce or stop azelastine if sedation is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Clozapine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Clozapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clozapine is strongly sedating and anticholinergic, and azelastine may add drowsiness. The combination can increase sedation and impair psychomotor function.
How serious is the interaction between Azelastine-fluticasone and Clozapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and advise on driving. Reduce or stop azelastine if sedation is problematic.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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