Drug interactions
Azelastine-fluticasone + Diphenoxylate
Severity: Moderate
Azelastine-fluticasone and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid antidiarrheal that can cause drowsiness and CNS depression at higher exposure. Azelastine may increase sedation when combined.
What this interaction means in plain words
Azelastine-fluticasone and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid activity and H1 antagonism.
What to do
Counsel on drowsiness and avoid driving until the response is known. Monitor sedation, especially in children and older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Azelastine-fluticasone with Diphenoxylate?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid antidiarrheal that can cause drowsiness and CNS depression at higher exposure. Azelastine may increase sedation when combined.
How serious is the interaction between Azelastine-fluticasone and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on drowsiness and avoid driving until the response is known. Monitor sedation, especially in children and older adults.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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