Drug interactions
Azelastine-fluticasone + Ketotifen
Severity: Minor
Azelastine-fluticasone and Ketotifen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketotifen is an antihistamine that can cause drowsiness when taken orally, and azelastine adds to sedation. With the ophthalmic form, systemic exposure is minimal and the additive effect is small.
What this interaction means in plain words
Azelastine-fluticasone and Ketotifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Ketotifen belongs to Respiratory.
Why it happens
Possible additive H1-antihistamine sedation, limited by low systemic exposure with ophthalmic use.
What to do
Counsel about possible drowsiness, especially if oral ketotifen is used. Avoid driving if sedated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Ketotifen
- Ketotifen + Phenobarbital Moderate
- Ketotifen + Pholcodine Moderate
- Ketotifen + Primidone Moderate
- Ketotifen + Protriptyline Moderate
- Ketotifen + Quazepam Moderate
- Ketotifen + Rotigotine Moderate
Frequently asked questions
Can I take Azelastine-fluticasone with Ketotifen?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Ketotifen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketotifen is an antihistamine that can cause drowsiness when taken orally, and azelastine adds to sedation. With the ophthalmic form, systemic exposure is minimal and the additive effect is small.
How serious is the interaction between Azelastine-fluticasone and Ketotifen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about possible drowsiness, especially if oral ketotifen is used. Avoid driving if sedated.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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