Drug interactions
Azelastine-fluticasone + Mavacamten
Severity: Minor
Azelastine-fluticasone and Mavacamten: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azelastine may weakly inhibit CYP2C19 and could raise mavacamten exposure. Higher mavacamten levels can lower left ventricular ejection fraction and cause heart failure, but the effect of a nasal spray is probably small.
What this interaction means in plain words
Azelastine-fluticasone and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azelastine-fluticasone belongs to Respiratory; Mavacamten belongs to Cardiovascular.
Why it happens
Possible weak CYP2C19 inhibition reduces mavacamten metabolism.
What to do
Continue routine echocardiographic monitoring of left ventricular ejection fraction. Reassess mavacamten dosing if function declines after azelastine is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Azelastine-fluticasone with Mavacamten?
MediHelp rates the interaction as minor. Azelastine-fluticasone and Mavacamten have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azelastine may weakly inhibit CYP2C19 and could raise mavacamten exposure. Higher mavacamten levels can lower left ventricular ejection fraction and cause heart failure, but the effect of a nasal spray is probably small.
How serious is the interaction between Azelastine-fluticasone and Mavacamten?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue routine echocardiographic monitoring of left ventricular ejection fraction. Reassess mavacamten dosing if function declines after azelastine is started.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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