Drug interactions
Azelastine-fluticasone + Morphine
Severity: Moderate
Azelastine-fluticasone and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Morphine causes sedation and respiratory depression, and azelastine may add to drowsiness. The combination may increase CNS depression and reduce alertness.
What this interaction means in plain words
Azelastine-fluticasone and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azelastine-fluticasone belongs to Respiratory; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and antihistamine sedation.
What to do
Monitor sedation and respiratory rate, particularly at initiation or after dose increases. Advise avoidance of alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azelastine-fluticasone
- Azelastine-fluticasone + Calcium / magnesium / potassium / sodium oxybates Major
- Azelastine-fluticasone + Sodium oxybate Major
- Alfentanil + Azelastine-fluticasone Moderate
- Alprazolam + Azelastine-fluticasone Moderate
- Amitriptyline + Azelastine-fluticasone Moderate
- Amobarbital + Azelastine-fluticasone Moderate
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Azelastine-fluticasone with Morphine?
MediHelp rates the interaction as moderate. Azelastine-fluticasone and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Morphine causes sedation and respiratory depression, and azelastine may add to drowsiness. The combination may increase CNS depression and reduce alertness.
How serious is the interaction between Azelastine-fluticasone and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, particularly at initiation or after dose increases. Advise avoidance of alcohol and driving until the response is known.
What other medicines interact with Azelastine-fluticasone?
MediHelp also lists interactions of Azelastine-fluticasone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Azelastine-fluticasone page.
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