Drug interactions
Azilsartan + Canagliflozin-metformin
Severity: Moderate
Azilsartan and Canagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azilsartan can raise serum potassium, and canagliflozin may add to this in patients with reduced renal function. The combination also raises volume depletion and renal function concerns.
What this interaction means in plain words
Azilsartan and Canagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan belongs to Cardiovascular; Canagliflozin-metformin belongs to Endocrine.
Why it happens
Angiotensin receptor blockade reduces aldosterone-mediated potassium excretion, with possible additive effects.
What to do
Monitor potassium, creatinine and volume status after initiation and dose changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Canagliflozin-metformin?
MediHelp rates the interaction as moderate. Azilsartan and Canagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azilsartan can raise serum potassium, and canagliflozin may add to this in patients with reduced renal function. The combination also raises volume depletion and renal function concerns.
How serious is the interaction between Azilsartan and Canagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, creatinine and volume status after initiation and dose changes.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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