Drug interactions
Azilsartan + Enoxaparin
Severity: Moderate
Azilsartan and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparins can suppress adrenal aldosterone secretion, which may cause potassium retention. Combined with an angiotensin receptor blocker the risk of hyperkalemia rises, especially in renal impairment or diabetes.
What this interaction means in plain words
Azilsartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan belongs to Cardiovascular; Enoxaparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis adds to the reduced aldosterone effect from angiotensin receptor blockade, causing potassium retention.
What to do
Monitor serum potassium and renal function, particularly with prolonged enoxaparin use or in patients with kidney disease or diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Azilsartan with Enoxaparin?
MediHelp rates the interaction as moderate. Azilsartan and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Low molecular weight heparins can suppress adrenal aldosterone secretion, which may cause potassium retention. Combined with an angiotensin receptor blocker the risk of hyperkalemia rises, especially in renal impairment or diabetes.
How serious is the interaction between Azilsartan and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly with prolonged enoxaparin use or in patients with kidney disease or diabetes.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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