Drug interactions
Azilsartan + Lisinopril
Severity: Major
Azilsartan and Lisinopril: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an ACE inhibitor with an ARB gives dual renin-angiotensin system blockade, increasing hypotension, hyperkalemia and acute kidney injury risk.
What this interaction means in plain words
Azilsartan and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan belongs to Cardiovascular; Lisinopril belongs to Cardiovascular.
Why it happens
Additive blockade of the renin-angiotensin-aldosterone system at two levels.
What to do
Avoid the combination; use one agent. If unavoidable, monitor potassium and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Lisinopril?
MediHelp rates the interaction as major. Azilsartan and Lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ACE inhibitor with an ARB gives dual renin-angiotensin system blockade, increasing hypotension, hyperkalemia and acute kidney injury risk.
How serious is the interaction between Azilsartan and Lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use one agent. If unavoidable, monitor potassium and renal function.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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