Drug interactions
Azilsartan + Lofexidine
Severity: Moderate
Azilsartan and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, and lofexidine also reduces heart rate. Combined use can cause additive hypotension, dizziness, syncope and bradycardia.
What this interaction means in plain words
Azilsartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic blood pressure lowering from angiotensin receptor blockade plus central alpha-2 agonism with sympatholytic bradycardic effects.
What to do
Monitor blood pressure and pulse when lofexidine is started or adjusted, and warn the patient about orthostatic symptoms. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Azilsartan with Lofexidine?
MediHelp rates the interaction as moderate. Azilsartan and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, and lofexidine also reduces heart rate. Combined use can cause additive hypotension, dizziness, syncope and bradycardia.
How serious is the interaction between Azilsartan and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and pulse when lofexidine is started or adjusted, and warn the patient about orthostatic symptoms. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Azilsartan?
MediHelp also lists interactions of Azilsartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Azilsartan page.
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