Drug interactions
Azilsartan + Tadalafil
Severity: Minor
Azilsartan and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil may add modestly to the blood pressure lowering of azilsartan. Symptomatic hypotension is uncommon but possible, especially with volume depletion.
What this interaction means in plain words
Azilsartan and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilation from PDE5 inhibition and angiotensin receptor blockade.
What to do
Monitor blood pressure after tadalafil is started and advise reporting dizziness or fainting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Azilsartan
- Aliskiren + Azilsartan Contraindicated
- Azilsartan + Sparsentan Contraindicated
- Amifostine + Azilsartan Major
- Amlodipine-benazepril + Azilsartan Major
- Amlodipine-perindopril + Azilsartan Major
- Azilsartan + Benazepril Major
Frequently asked questions
Can I take Azilsartan with Tadalafil?
MediHelp rates the interaction as minor. Azilsartan and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil may add modestly to the blood pressure lowering of azilsartan. Symptomatic hypotension is uncommon but possible, especially with volume depletion.
How serious is the interaction between Azilsartan and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after tadalafil is started and advise reporting dizziness or fainting.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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