Drug interactions
Azilsartan-chlorthalidone + Calcium acetate
Severity: Moderate
Azilsartan-chlorthalidone and Calcium acetate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone reduces urinary calcium excretion, so calcium salts may raise serum calcium. Hypercalcemia is more likely with high doses, renal impairment or vitamin D therapy.
What this interaction means in plain words
Azilsartan-chlorthalidone and Calcium acetate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Calcium acetate belongs to Genitourinary.
Why it happens
Thiazide-type diuretics increase distal tubular calcium reabsorption, reducing calcium excretion.
What to do
Monitor serum calcium periodically and reduce the calcium dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Calcium acetate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Calcium acetate?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Calcium acetate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone reduces urinary calcium excretion, so calcium salts may raise serum calcium. Hypercalcemia is more likely with high doses, renal impairment or vitamin D therapy.
How serious is the interaction between Azilsartan-chlorthalidone and Calcium acetate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and reduce the calcium dose if hypercalcemia develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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