Drug interactions
Calcium acetate + Candesartan-hydrochlorothiazide
Severity: Moderate
Calcium acetate and Candesartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, so taking them with calcium salts can raise serum calcium. Hypercalcemia is more likely with high calcium doses, renal impairment, or when vitamin D is also used.
What this interaction means in plain words
Calcium acetate and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium acetate belongs to Genitourinary; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides enhance distal tubular calcium reabsorption, decreasing urinary calcium loss.
What to do
Monitor serum calcium periodically, especially with high-dose calcium or renal impairment, and reduce calcium or vitamin D dosing if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Calcium acetate
Frequently asked questions
Can I take Calcium acetate with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Calcium acetate and Candesartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, so taking them with calcium salts can raise serum calcium. Hypercalcemia is more likely with high calcium doses, renal impairment, or when vitamin D is also used.
How serious is the interaction between Calcium acetate and Candesartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially with high-dose calcium or renal impairment, and reduce calcium or vitamin D dosing if hypercalcemia develops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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