Drug interactions
Azilsartan-chlorthalidone + Chlorpropamide
Severity: Moderate
Azilsartan-chlorthalidone and Chlorpropamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone may raise blood glucose and reduce the effect of chlorpropamide. Both drugs can also cause hyponatremia, so combined use may increase this risk.
What this interaction means in plain words
Azilsartan-chlorthalidone and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Chlorpropamide belongs to Endocrine.
Why it happens
Thiazide-related hyperglycemia opposes sulfonylurea action, and both agents can cause hyponatremia via ADH-related effects and renal sodium loss.
What to do
Monitor blood glucose and serum sodium after starting the combination. Adjust the antidiabetic regimen or choose a different sulfonylurea if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Chlorpropamide?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Chlorpropamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone may raise blood glucose and reduce the effect of chlorpropamide. Both drugs can also cause hyponatremia, so combined use may increase this risk.
How serious is the interaction between Azilsartan-chlorthalidone and Chlorpropamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum sodium after starting the combination. Adjust the antidiabetic regimen or choose a different sulfonylurea if problems arise.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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