Drug interactions
Azilsartan-chlorthalidone + Dexamethasone
Severity: Moderate
Azilsartan-chlorthalidone and Dexamethasone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone and chlorthalidone both can lower potassium, so combined use may increase hypokalemia. Hypokalemia may provoke arrhythmias, especially in patients with heart disease or on QT-prolonging drugs.
What this interaction means in plain words
Azilsartan-chlorthalidone and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Dexamethasone belongs to Endocrine.
Why it happens
Additive renal potassium wasting; glucocorticoid effects add to thiazide-like kaliuresis.
What to do
Monitor serum potassium during systemic corticosteroid courses and replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Dexamethasone
- Bcg vaccine live + Dexamethasone Contraindicated
- Dexamethasone + Mifepristone Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexamethasone + Smallpox vaccine live Contraindicated
- Dexamethasone + Varicella virus vaccine live Contraindicated
- Dexamethasone + Yellow fever vaccine Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Dexamethasone?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Dexamethasone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexamethasone and chlorthalidone both can lower potassium, so combined use may increase hypokalemia. Hypokalemia may provoke arrhythmias, especially in patients with heart disease or on QT-prolonging drugs.
How serious is the interaction between Azilsartan-chlorthalidone and Dexamethasone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during systemic corticosteroid courses and replace potassium as needed.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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